Our data also suggested that severe SARS-CoV-2 infection largely silenced the response of type I interferons (IFNs) and . Cryo-EM analysis has re-vealed that the analyzed COVID-19 spike protein has two conformations, one before it infects the host cell, and another during the infection. Direct infection of brain cells is not frequent except for the supportive astrocyte type of microglial cells. and the methods for locking spike proteins for many years. It's just one of a growing list of God-given natural plants that bring hope for healing and protection in this fear-laced covid era. . No such inflammatory response was observed in response to membrane (M), envelope (E), and nucleocapsid (N) proteins. You will find the scientific literature referencing the dangers of "SARS-COV2" are interchanging that term with "spike protein" PubMed is full of papers explaining how the inflammatory "spike protein" attaches to an enzyme in the cardiovascular (and other) systems (the angiotensin converting enzyme 2). The spike protein binds to the ACE2 receptor on cells, downregulates their function, and causes damage to the endothelium cells that line lung tissue and blood vessels. Pfizer and Moderna COVID-19 vaccines are the only mRNA vaccines approved or authorized for booster use in the United States. The study found expected inflammation associated with an immune response and concluded the shot was safe. Inflammation and Antiviral Immune Response Associated With Severe Progression of COVID-19 . It is immune activation that continues even after the initial injury is gone, it is very problematic. "Spike protein is a deadly protein," Dr. Peter McCullough, an internist, cardiologist and trained epidemiologist, says in a video. The structural change of the spike protein is triggered by binding . The Canadian . At the same time the Platelets stick together. A purified spike (S) glycoprotein of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) coronavirus was used to study its effects on THP-1 macrophages, peripheral blood mononuclear cells (PBMCs), and HUVEC cells. 3.4 Cannabidiol inhibits spike protein-induced epithelial damage rescuing tight junction occludin and ZO-1 expression Following SP challenge (10 ng/ml), a significant and time-dependent reduction of TEER was observed starting from 3 h and in the subsequent time intervals at 6, 9, 12, 15, 18, 21, and 24 h in confrontation with the vehicle group. This explains the symptoms of the Long COVID Syndrome. "Surprisingly, only spike protein but no nucleocapsid protein could be detected within the foci of inflammation in both the brain and the heart, particularly in the endothelial cells of small blood vessels. In new work from Temple scientists, they show that the spike proteins that extrude from SARS-CoV-2 promote inflammatory responses on the endothelial cells that form the blood-brain barrier. With a size of 180-200 kDa, the Spike protein has been found in the human heart and is believed to be the causative agent for the burgeoning epidemic of heart inflammation that has a 90% male predominance, peak incidence at ages 18-24 but can extend down to toddlers and up to men over age 65 years. But new research obtained by a group of It caused the Red Blood Cells to stick together. Spike proteins can cause chronic inflammation. About three weeks ago, antivaxxers started pointing to a study from the Salk Institute as yet more "proof" that the spike protein used in COVID-19 vaccines is toxic and deadly. SARS-CoV-2 spike protein-induced heart inflammation may originate from either COVID-19 infection or the administration of COVID-19 mRNA vaccines. Although COVID-19 has become a major challenge to global health, there are currently no efficacious agents for effective treatment. Preprint Authors Shahanshah Khan 1 , Mahnoush S Shafiei 1 , Christopher Longoria 2 , John Schoggins 3 , Rashmin C Savani 2 , Hasan Zaki 1 Affiliations Thrombotic complication has been an important symptom in critically ill patients with COVID-19. The spike protein churned out by the body's cells in response to the mRNA contain a fully-functional s1 binding sub-unit . We observed that spike (S) protein potently induces inflammatory cytokines and chemokines including IL-6, IL-1, TNFa, CXCL1, CXCL2, and . THE SPIKE PROTEIN AS SOURCE OF CONSTANT INJURY AND CHRONIC INFLAMMATION The Relation to HIV and the Fibrosed Thymus July 3, 2022 Chronic inflammation happens when the immune system doesn't turn off after an injury or triggering event is over. A Tel Aviv-based start-up company claims it has proven in lab results that a combination of plant-based "natural compounds" can decompose the COVID-19 spike protein that . The Spike protein and inflammation both may be increasing the risk of a leaky blood brain barrier being present in severe COVID-19 or LongCovid. Via Children's Health Defense COVID vaccine researchers had previously assumed mRNA COVID vaccines would behave like traditional vaccines. Further study demonstrates the effect of the spike protein. In healthy individuals, pea protein has actually been shown to reduce inflammation, because of its low Ph levels. Viral spike protein and inflammation. The researchers sought to determine if the spike protein was the underlying cause of the . . The body's own immune system, again, is attacking the Spike Proteins which causes the mass inflammation of the brain and the destruction of the spike-infested brain cells. There is also concern that the spike proteins cause inflammation in the reproductive system of women, interfering with important protein synthesis that's needed for healthy menstrual cycles. Further Study Demonstrates the Effect of the Spike Protein. The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. The fact that it is found on exosomes for at least 4 months after the 2nd injection means that the patient could suffer from chronic inflammation in the organs which express these spike proteins. . So, by vaccinating people we are inadvertently inoculating them with a toxin." . Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls. (HA) of H1N1 virus, the regulation pattern of these genes was unique in PBMCs response to Spike protein of SARS-CoV-2 ex vivo. . The vaccine's spike protein responsible for infection and its most severe symptoms would remain mostly in the injection site at the shoulder muscle or local lymph nodes. The spike protein is the cytotoxin and the disease causing portion of the pathogen. Surprisingly, the intravenous route induced apoptotic cell death as well as minor spike protein expression in heart muscle cells, inflaming the heart muscles; that is, myocarditis. "The S protein plays a crucial role in penetrating host cells and initiating infection.". This paper identified a spike protein as causal factor in clotting. Since no nucleocapsid protein could be detected, the presence of spike protein must be ascribed to vaccination rather than to viral infection. The eminent Dr. Peter McCollough, a truly great medical expert, has addressed micro clots. The S1 Proteins can persist in CD16+ Monocytes up to 15 Months Post-Infection and vaccination to induce chronic inflammation. And so spike protein in the naturally occurring SARS-COV2 viral infection has been shown to cause brain inflammation and neurological damage, heart attacks, lung disease, liver disease, kidney disease, and interacting with the male and female reproductive systems, along with affecting blood binding to oxygen and blood clotting. Now, researchers have found that the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to heart muscle injury through the inflammatory process, according to preliminary research to be presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2022. In May, Canada authorized the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. 1A). WT type instilled with S1SP exhibited a significant but less pronounced decrease (Fig. But recent studies in animals and cultured cells have found . Some teenagers experienced a type of heart inflammation called myocarditis after they got inoculated. A purified spike (S) glycoprotein of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) coronavirus was used to study its effects on THP-1 macrophages, peripheral blood mononuclear cells (PBMCs), and HUVEC cells.The S protein mediates the entry of SARS-CoV-2 into cells through binding to the angiotensin-converting enzyme 2 (ACE2) receptors. An example, of individuals who should avoid . We observed that spike (S) protein potently induced inflammatory cytokines and chemokines, including IL-6, IL-1, TNF, CXCL1, CXCL2, and CCL2, but not IFNs in human and mouse macrophages. The article was titled The amyloid cascade-inflammatory hypothesis of Alzheimer disease (AD): implications for therapy. The spike protein is an arm-like apparatus that the virus uses to attach to and enter healthy cells. Spike protein is a toxin. Then, a second paper 16 was published online March 8, 2021, investigated the potential that the spike protein is an inflammagen, or an irritant that can trigger inflammation at the cellular level. Nigella sativa, also known as black seed or black cumin seed, "strongly binds" to ACE2 receptors in the lungs, and effectively stops coronavirus (Covid-19) from causing inflammation and vascular damage. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection relies on the binding of S protein (Spike glycoprotein) to ACE (angiotensin-converting enzyme) 2 in the host cells. Spike protein damages endothelial cells and hurts heart. Here we investigated direct inflammatory functions of major structural proteins of SARS-CoV-2. For instance, behold Alex Berenson, the " pandemic's wrongest man ", crowing about the study: "We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. As pyrroloquinoline quinone (PQQ) is a scavenger of free radicals, redox cofactor, and antioxidant which supports cognitive and mitochondrial functions, supplementation with PQQ could have a positive . But it is provable the Spike Protein is being delivered in the Killer Jabs which are not vaccines, and it is killing tens of thousands and making sick/disabling millions. Spike proteins can cause chronic inflammation. (a-c) The protein expression levels of IL-6, IL-8, and TNF- in SARS-CoV-2 spike pseudovirions-infected HEK293T, HEK293T-hACE2, Vero E6, 16HBE, and HMEC-1 cells pretreated with DMSO or 3-MA (10 mM) were quantified using ELISA. Perhaps the most important information, in relation . Pea protein is not normally inflammatory. If we review the article carefully, we can infer how the Spike Protein of SARS-CoV-2 is not only able to induce amyloidosis, but also to rapidly accelerate its progression. We measured the viability . The spike protein can cause inflammation by activating the alternate complement pathway. A second study published in December, 2020, in Neurobiology of Disease reported that the SARS-CoV-2 spike proteins showed a direct negative impact on endothelial cells and provide "plausible explanations" for the neurological consequences observed . . SARS-CoV-2 infection induces EC inflammation, leading to endotheliitis. The spike protein is the main infectivity and virulence factor. Advertisement. But what has that got to do with the vaccine? SARS-CoV-2 and its Spike protein directly stimulated platelets to facilitate the release of coagulation factors, the secretion of inflammatory factors, and the formation of leukocyte-platelet aggregates. So antibodies created against . Although a recent study showed . Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic . The viral membrane proteins are closely related to the virulence of the disease. During infection, the spike proteins bind with receptors on cells in our body, starting a process that allows the virus to release its genetic material into the inside of the healthy cell. The researchers sought to determine if the spike protein was the underlying cause of the . It may cause inflammation and clotting in any tissue in which . The injected spike protein was also found in the lung, spleen, kidney and liver of the mice. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-B pathway bioRxiv. And the mRNA-induced spike protein can bind to brain tissue 10 to 20 times stronger than the spike proteins that are (naturally) part of the original virus. Please stop trusting the experiment. Research points to interleukin 6 (IL-6) as a crucial signature of the cytokine storm, and the clinical use of the IL-6 inhibitor . Moreover, if spike proteins are not neutralized by the immune system, they can escape the body of the vaccinated, shedding and attaching to other people . The brain is very much at risk for severe COVID-19 or LongCovid patients. The researchers . [ 19] Amyloids formation and interaction 10. . One study shows the spike protein can invade and live in the neural tissue, infecting neurons and causing neurotropism. This finding provides evidence for the hypothesis that SARS-CoV-2 can persist in the body through viral reservoirs, where it continues to release spike protein and trigger inflammation. 2021 Mar 17;2021.03.16.435700. doi: 10.1101/2021.03.16.435700. Cytokine storm syndrome (CSS) can lead to acute respiratory distress syndrome (ARDS), which contributes to most COVID-19 mortalities. Cells make up tissues, different tissues form organs, and. No such inflammatory response was observed in response to membrane (M), envelope (E), and nucleocapsid (N) proteins. More research has been revealed over the last year about the odd blood clotting risks found with COVID-19 compared to SARS-1 which had been primarily a respiratory illness. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. The study, published in the December print issue of the journal Neurobiology of Disease, is the first to show that SARS-CoV-2 spike proteins can cause this barrier to become "leaky," The spike protein is located on the outside of a coronavirus and is how SARS-CoV-2 (the coronavirus) enters human cells. Whelan specializes in treating children with multisystem inflammatory syndrome (MIS-C . Third , as these experimental vaccines produce many trillions of spike proteins in their recipients, these vaccinated individuals "can shed some of these (spike protein) particles to . And a unique type of Coagulation. Studies have shown that inflammation can lead to cell stress, damage, and even death. And, of course, a spike . Its location on the outside of the virus makes it so the immune system can recognize it easily. If we review the article carefully, we can infer how the Spike Protein of SARS-CoV-2 is not only able to induce amyloidosis, but also to rapidly accelerate its progression. SARS-Spike-Tri is short for the spike protein trimer of SARS-CoV. Research has found SARS-CoV-2 spike protein alone to be a potent inductor of endothelial dysfunction, suggesting that "manifestations of COVID-19 shock syndrome in children can be at least partially attributed to its action." Let's now circle back to the concerns voiced by Whelan in his letter to the FDA: The Spike Protein is a "uniquely dangerous" transmembrane fusion protein that is an integral part of the SARS-CoV-2 virus. Heart inflammation and shortness of breath has been occurring after receiving the spike mRNA injections in . The inflammatory spike proteins are now being replicated in human cells, subverting the natural protein synthesis of the cells, while leaking into the bloodstream and accumulating in vital organs. The research shows how the molecular structure and sequence of the SARS-CoV-2 spike protein -- part of the virus that causes COVID-19 -- could be behind the inflammatory syndrome cropping up in . The . SARS-CoV-2 spike induces inflammation and apoptosis through enhanced autophagy. In Acta Neuropathologica, an article was published in September of 2013.The article was titled The amyloid cascade-inflammatory hypothesis of Alzheimer disease (AD): implications for therapy. 1,5 Because S protein decreased ACE2 level and impaired NO bioavailability, . Incubation of human umbilical vein EC with whole spike, its receptor-binding domain, or the integrin-binding tripeptide RGD induced the nuclear translocation of NF-B and enhanced the expression . [ 20] Long COVID-Syndrome 9. Dr. J. Patrick Whelan is a pediatric rheumatologist who warned the FDA of the microvascular injury the vaccine may cause to the kidneys, brain, liver and heart before it was released to the public. Studies have shown that inflammation can lead to cell stress, damage, and even death. It also damages the cells in the lining of the blood vessel walls which leads to blood clots, bleeding, massive inflammation . The Spike Proteins from the vax are binding to the brain cells and this has resulted in another major organ inflammatory response. Experts say the tiny level of spike protein measured in the bloodstream of vaccinated . The spike protein is unique to SARS-CoV-2 - it doesn't look like other proteins your body makes. The deadly spike protein, take two. The CDC has stated that the spike protein of SARS-CoV-2 is harmless, which assures that current Covid-19 vaccines would be safe. The S protein mediates the entry of SARS-CoV-2 into cells through binding to the angiotensin-converting enzyme 2 (ACE2) receptors. According to Dr. Ryan Cole, messenger RNA (mRNA) vaccines produce persisting spike protein that may cause severe damage to the recipient's health, such as unusual clotting, heart inflammation, or cancer. According to Dr. Ryan Cole, messenger RNA (mRNA) vaccines produce persisting spike protein that may cause severe damage to the recipient's health, such as unusual clotting, heart inflammation, or cancer. Spike Protein Induces Alveolar Inflammation and Acute Lung Injury. n qRT-PCR analysis for the expression of IL1B in THP-1 cells infected with 1 10 7 PFU/mL HCoV-229E for 2 h, with or without 100 . Top 10 Spike Protein Detox . Here, we show that the spike protein of SARS-CoV-2 alone activates the EC inflammatory phenotype in a manner dependent on integrin 51 signaling. Pathogenesis of COVID-19 is associated with a hyperinflammatory response; however, the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. For instance, Pfizer's biodistribution study, which was used to determine where the injected substances end up in the body, showed the COVID spike protein from the shots accumulated in "quite high concentrations" in the ovaries. It may cause inflammation and clotting in any tissue in which it accumulates. We observed that spike (S) protein potently induced inflammatory cytokines and chemokines, including IL-6, IL-1, TNF, CXCL1, CXCL2, and CCL2, but not IFNs in human and mouse macrophages. The protein -- an ion channel that spans the membrane of immune cells -- presents a new target for the development of drugs that can restrain overblown inflammatory responses. K18-hACE2 mice instilled with S1SP displayed a rapid and sustained decline in body weight, unlike mice receiving SP or saline. However, individuals told to avoid foods with high levels of purine and those who are allergic or intolerant to peas may suffer from inflammation. Then, a second paper published online March 8, investigated the potential that the spike protein is an inflammagen, or an irritant that can trigger inflammation at the cellular level. Yes. The damage is apparently caused by effects on the mitochondria (energy producing organelles) in the cells - they change their shape and have reduced function. . There are a number of studies that indicate spike. Worse, reports of Guillain-Barre syndrome and other neurological . Pfizer and Moderna COVID-19 vaccines are the only mRNA vaccines approved or authorized for booster use in the United States. Cells make up tissues, different tissues form organs, and organs are part of our own physiological systems. Therefore spike protein injuries are a systemic syndrome. Early in the pandemic he noted that "the Spike Protein itself caused Coagulation or Blood Clotting. May 31, 2021 ( LifeSiteNews) New research shows that the coronavirus spike protein from COVID-19 vaccination unexpectedly enters the bloodstream, which is a plausible explanation for thousands .

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